Jeffrey Ravetch, Head of the Leonard Wagner Laboratory of Molecular Genetics and Immunology at Rockefeller, has been studying the paradox of IVIG: immunoglobulin (Ig)G antibodies, which trigger autoimmune diseases, are what give IVIG its anti-inflammatory properties when pooled from healthy donors. After pinning down the molecular mechanism at the source of the contradiction — a single sugar molecule located at the very tip of some IgG antibodies — Ravetch and his collaborators produced an engineered IgG molecule that was 30 times more effective than IVIG alone when given to arthritic mice. "This paper provides a clear route for developing an alternative for IVIG, which could be of great benefit to patients with autoimmune diseases," says Ravetch.

The technology has been licensed to Centaurus Pharmaceuticals (MA, USA), which is working to develop a product that can be used in clinical trials. Ravetch is confident that the resulting drug could potentially provide relief for a variety of patients, especially for those where IVIG has little effect. In lupus, the current preparation has such low activity that the amount required to effect a noticeable difference exceeds the amount that can be realistically derived from the blood supply. However, according to Ravetch: "With the recombinant form you can make an unlimited, potent supply."