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Many
Epilepsy syndromes are autoimmune and easily and permanently
treatable please read our e-book .
Prof. Alan EBRINGER,B.Sc, MD, FRCP, FRACP,
FRCPath, HonFRSHKing’s College LondonYour Royal Highnesses, Mr.
Chairman, Ladies and Gentlemen.I would like to thank The Royal
Society for the Promotion of Health for the great honour it has
bestowed on me in awarding the Donaldson Gold Medal to me for the
work from our group,on “Bovine Spongiform Encephalopathy or BSE or
morecommonly known as MAD COW DISEASE. This work is a credit to the
outstanding group of research workers in our Unit, especially Dr.
Clyde WILSON , who recently was elected a Member of the “Royal
College of Pahologists” rather than to anything I may have done
personally.I graduated in Medicine from the University of Melbourne
way back in 1962, obtained a Travelling Scholarship from the “Royal
Australasian College of Physicians” to come to the U.K. and I have
been working in the University of London since 1970.Over the last
thirty years, our group has been studying the autoimmune
diseases, ANKYLOSING SPONDYLITIS, a chronic condition characterized
by backache and also another arthritic disease RHEUMATOID ARTHRITIS.
We have found thatANKYLOSING SPONDYLITIS is triggered by the bowel
microbe KLEBSIELLLAand RHEUMATOID ARTHRITIS is produced following a
urinary tract infection by the microbe PROTEUS.Prof. Feltkamp from
Amsterdam in the Netherlands, asked us to cooperate in a joint
study, which showed that Dutch patients with ANKYLOSING SPONDYLITIS
have antibodies to KLEBSIELLA and Dutch patients with RHEUMATOID
ARTHRITIS have antibodies to PROTEUS, as do English patients. These
results have beenpublished.In AUTOIMMUNE DISEASES patients have
antibodies which attack their own organs and these are called
AUTOANTIBODIES. Our model for studying autoimmunediseases was
RHEUMATIC FEVER, which is caused by the microbeSTREPTOCOCCUS, which
infects the tonsils and has components which resemble the human
heart.Following a STREPTOCOCCAL TONSILLITIS antibodies are produced
which attack not only the microbe itself but also the human heart
and cause RHEUMATIC FEVER.Thus MOLECULAR MIMICRY or similarity
between a microbe and a target organ produces an AUTOIMMUNE
DISEASE.RHEUMATIC FEVER is no longer a problem in the Western world
becauseSTREPTOCOCCAL TONSILLITIS responds to antibiotics but in
countries of theThird World where access to such drugs is
financially prohibitive, the disease remains a serious problem.
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We have used this concept of MOLECULAR MIMICRY to identify the
trigger factors in RHEUMATOI ARTHRITIS and ANKYLOSING
SPONDYLITIS.Over the last seven years, our group has been studying
“bovine spongiformencephalopathy” (BSE), also known as MAD COW
DISEASE. A computer analysis showed that the soil and skin microbe
ACINETOBACTER has components whichresemble brain tissues.We
approached MAFF (Ministry of Agriculture, Fisheries and Food) with
the idea that we had an alternative theory , an AUTOIMMUNE THEORY,
to the PRIONHYPOTHESIS, which could explain the origin of BSE.
Despite a few objections from some quarters, some funds were made
available and access given to BSE material.A study of BSE affected
cattle showed that they have elevated levels of antibodies to the
soil bacterium ACINETOBACTER, a microbe which has components
resembling brain tissues and to a lesser extent to the related
microbe PSEUDOMONAS..So far we have studied 508 animals; 218 with
BSE and compared them to 290 controls. These results are specific
since the BSE animals do not show antibody elevations to five other
microbes: KLEBSIELLA, PROTEUS, SERRATIA, E.COLI, BACILLUS and
AGROBACTERIUM.The elevated levels of antibodies to ACINETOBACTER
found in BSE cattle lends itself to the development for an
ANTE-MORTEM TEST for “BSE”,It has been proposed that BSE is caused
by exposure to ACINETOBACTER fragments, found in the
“meat-and-bonemeal” flour meal fed to cattle.The hypothesis is that
antibodies against ACINETOBACTER, attack the brain and cause MAD COW
DISEASE.The first time that a BSE cow was observed, it was found to
be standing on its forelegs but falling down by its hindquarters and
in this it resembles MULTIPLE SCLEROSIS patients who have a greater
incidence of lower limb paralysis.Patients with MULTIPLE SCLEROSIS
were also found to have antibodies toACINETOBACTER and to the
related microbe PSEUDOMONAS.Over 50% of patients with MULTIPLE
SCLEROSIS suffer from SINUSITIS and thus could have become infected
by the saprophytic microbe ACINETOBACTER.The general hypothesis is
proposed that BSE is MULTIPLE SCLEROSIS in cows and therefore it is
an autoimmune disease which CANNOT BE TRANSMITTED BY THE CONSUMPTION
OF “BSE” AFFECTED MEAT.If this theory can be confirmed then the
following conclusions arise:(1)Consumption of meat is safe and has
always been safe.
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(2)Culling of cattle was unnecessary.(3)There will be no epidemic of
CJD.(4)An ante-mortem test for detecting BSE in live cattle is
feasible. Clearly the autoimmune theory of BSE requires further
investigations but two months ago, DEFRA withdrew research funds for
such studies.We are currently cooperating with our Dutch colleagues
in studying patients withMULTIPLE SCLEROSIS.We hope that such
Anglo-Dutch studies will continue in the future and serve not only
international cooperation but also the aims and mission of the Royal
Society for the Promotion of Health.Thank you for your attention.
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